Drug-resistance mechanisms and tuberculosis drugs

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منابع مشابه

Drug-resistance mechanisms and tuberculosis drugs.

Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QW, UK (CUK, BJ, SJP, MET); School of Medicine, Tsinghua University, Beijing, China (BJ); Faculty of Law, University of Cambridge, Cambridge, UK (KL); Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, UK (MJE, NMB, SJP, MET); Molecular Mycobacteriology, Research Center Bor...

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Drug Resistance Mechanisms in Mycobacterium tuberculosis.

Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the causative agent of the disease. In recent years, even more serious forms of drug resistance have been reported. A better knowledge of the mechanisms of drug resistance of M. tuberculosis and the relevant molecular mecha...

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Targeting Drug Resistance Mechanisms in Mycobacterium tuberculosis

Historically, tuberculosis (TB) has left a scar as mankind’s greatest infectious killer. With evidence of TB infection dating back nine millenia to a Neolithic Eastern Mediterranean settlement [1], this ancient disease meant almost certain death to those infected, a phenomenon spanning pre-antibiotic eras from the time of the Roman empire all the way to the beginning of the 20th century. But wi...

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Mechanisms of drug resistance in Mycobacterium tuberculosis.

Tuberculosis is a worldwide health problem posing increasing threat with the spread of HIV infection and drug resistant Mycobacterium tuberculosis strains. Consequently, control of this disease has become a significant challenge despite the availability of chemotherapy and BCG vaccine. Drug resistance for all first-line anti-tuberculosis agents and some second-line agents has been observed. Mor...

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Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs.

Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared as a global emergency in 1993 by the WHO, its control is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. More recently, severe forms of drug resistance such as extensively drug-resistant (XDR) ...

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ژورنال

عنوان ژورنال: The Lancet

سال: 2015

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(14)62450-8